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Oxiracetam

Oxiracetam is another piracetam analog. One study conducted in Japan compared the effects of piracetam and oxiracetam on normal mice learning a new task called discrete two-way shuttle avoidance. The mice had to learn to break a photo-beam whenever they heard a warning stimulus in order to avoid a mild electric shock. The optimum dose of oxiracetam for improving learning was 30mg per kilogram of body weight, whereas the optimum dose of piracetam was 100mg per kilogram (over three times as much).

An amazing study done in Italy attempted to find teratological (birth-defect causing) effects of oxiracetam. Pregnant mice were given oxiracetam from the beginning of their pregnancies until they gave birth. Controls were given saline solution instead. The offspring of the oxiracetam treated mice showed no negative effects at birth.

After one month, the offspring of oxiracetam treated mice (remember that the offspring themselves were not being given oxiracetam) showed signs of being more curious than the offspring of the controls. At three months, the oxiracetam offspring were performing significantly better in memory tests than the offspring of the controls.

Although this is not a recommendation for pregnant women to take oxiracetam, it certainly hints at exciting possibilities, and indicates that this is an amazing and non-toxic cognitive enhancer.

After elderly people with dementia were given oxiracetam for three months, several different tests were administered. The researchers wrote that oxiracetam is a 'vigilance-enhancing compound with some effects on spontaneous memory', and that 'in comparison with piracetam, oxiracetam exhibits a greater improvement in memory factor'.

Another oxiracetam study was performed on a large number of people. 307 people were enrolled originally and 272 people completed the study. Eight hundred milligrams of oxiracetam was given twice each day for a total of twelve weeks to patients suffering from primary degenerative, multi-infarct or mixed forms of dementia. They found significant improvements in memory and concentration.

In another study, oxiracetam and piracetam were each administered to 30 people (studying a total of 60 people). The dosage was a very large 6000mg per day. After 60 days of treatment, the researchers concluded that the tolerability of oxiracetam was excellent. They found that oxiracetam had better therapeutic results than piracetam on both psychosomatic and neurologic symptoms. Oxiracetam also seemed to decrease platelet aggregation..

Precautions: Oxiracetam, like other nootropics, is non-toxic. It has been shown to be safe in doses up to 2400mg.

Dosage: Oxiracetam is more potent than piracetam. In one study aimed at finding the optimum dosage subjects were tested with 200mg, 400mg, 800mg, 1200mg, and 2400mg. The greatest improvements in cognitive function occurred at doses of 1200mg and 2400mg per day.